To save laboratories time and resources, CLSI M22-A3 categorizes culture media into two distinct groups based on historical failure rates. 1. Exempt Media (Quality Controlled by Manufacturer)
Guaranteeing that culture media reliably supports the growth of pathogens while inhibiting normal flora as intended.
Quality Control for Commercially Prepared Microbiological Culture Media; Approved Standard, M22A3E, Published by CLSI, 2004-06-20 Go to product viewer dialog for this item. CLSI M22-A3-2004 (R2016) clsi m22a3 pdf
Ensuring non-target organisms are completely or partially inhibited.
: You can still find the full 44-page PDF version for purchase on the CLSI Shop or authorized retailers like the ANSI Webstore . To save laboratories time and resources, CLSI M22-A3
When you hold the official CLSI M22-A3 document—whether as a PDF on your lab computer or a printed manual—you hold the key to defensible, high-quality microbiology results. Don't compromise your lab's integrity with unauthorized copies. Invest in the standard, and your results will stand up to any audit.
All QC results must be logged. If a medium batch fails any parameter, the entire lot must be rejected, and the failure must be reported to the manufacturer. Evolution and the Transition to M22-A4 When you hold the official CLSI M22-A3 document—whether
For each organism, the standard specifies the ATCC or NCTC strain number, incubation conditions, and minimal expected performance.
Even if you have the CLSI M22-A3 PDF on your desk, labs frequently make errors in implementation.
Use the templates mentioned in Appendix B (once you access the PDF) or create your own that capture:
In clinical microbiology, the accuracy of diagnostic testing relies heavily on the quality of culture media. To ensure consistency and reliability, laboratories and manufacturers follow strict quality control (QC) guidelines. The definitive standard for this process is the Clinical and Laboratory Standards Institute (CLSI) document , titled "Quality Control of Commercially Prepared Culture Media."