Sone096 Full [updated] -
| Property | Value | |----------|-------| | | 2.8 | | pKa (phenolic OH) | 9.3 | | Solubility (water, 25 °C) | 12 µM | | Stability | Stable < 6 months at 4 °C, light‑sensitive (degrades ~10 % after 24 h UV‑A exposure) | | Spectroscopic data | ^1H NMR (400 MHz, DMSO‑d₆): δ 9.78 (s, 1H, NH), 8.62 (d, J = 5.2 Hz, 1H, pyridyl), 7.45‑7.30 (m, 4H, aromatic), 5.12 (s, 1H, CHOH), 3.86 (s, 3H, OCH₃). ^13C NMR confirms carbonyl at δ = 170 ppm. |
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1. **Friedel‑Crafts acylation** 4‑methoxy‑benzaldehyde + acetyl chloride → 4‑methoxy‑acetophenone (AlCl₃, 0 °C). This ensures that the creators and performers are
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