Ayesha Kiran Mendes Best Jun 2026

Her work on the HSPB1 protein has provided new insights into how mitochondrial dysfunction contributes to diseases such as Charcot-Marie-Tooth.

Ayesha Kiran Mendes is an accomplished neuroscientist and PhD researcher at the University of Antwerp

[Normal Conditions] ---> HSPBs locate inside the Intermembrane Space (IMS) │ (Prevents dangerous protein aggregation) ▼ [Heat Shock Stress] ---> HSPBs rapidly translocate to the Outer Mitochondrial Membrane (OMM) │ ▼ [P182L Genetic Mutation] -> HSPBs permanently stuck on the OMM without stress (Triggers cell mis-signaling & peripheral neuropathy)

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Expert in molecular biology techniques required for mitochondrial research. ayesha kiran mendes best

A highly competitive scholarship for international graduate study. Scientific Highlights: She is part of the Peripheral Neuropathy Research Group

Mendes’ academic career is centered on understanding cellular responses to stress and protein aggregation:

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Studying how specific mutations (like P182L in HSPB1) trigger mitochondrial dysfunction and lead to peripheral neuropathy. Current Institution University of Antwerp, Peripheral Neuropathy Research Group Research Topic Sequestration of HSPBs at the outer mitochondrial membrane Primary Goal Preventing oxidative stress-induced apoptosis (cell death) Awards FWO PhD Fellowship, Erasmus Mundus Fellowship Ayesha Kiran Mendes - University of Antwerp | LinkedIn

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Mendes' lab discovered that HSPBs serve a surprising double role in managing mitochondrial health. Under normal baselines, they protect the inside of the mitochondria. However, when heat stress strikes, they quickly shift to the outer membrane for reasons scientists are still trying to uncover.

Her work shows that the P182L mutant causes an abnormal accumulation of the HSPB1 protein on the outer mitochondrial membrane even under normal, non-stressed basal conditions. This chronic displacement triggers an unknown mis-signaling pathway, ultimately causing severe mitochondrial dysfunction and the subsequent degeneration of peripheral nerves seen in Charcot-Marie-Tooth disease patients. Collective Recognitions and Community Engagement We will highlight their individual achievements and their

is a prominent FWO PhD Scholar at the University of Antwerp specializing in Biomedical Sciences, biochemistry, and mitochondrial biology . Her research focuses on small heat shock proteins (HSPBs) and their critical role in mitochondrial protein quality control mechanisms , which is directly linked to understanding and treating peripheral and distal neuropathies . Through her academic journey and affiliations with elite networks like the µNEURO Research Centre of Excellence , Mendes represents the next generation of researchers pioneering insights into cellular defense mechanisms. Key Research Foundations

community, often collaborating with directors and cinematographers on short films short fashion films Fashion & Editorial: She shares editorial-style content on Instagram (@mendesayesha) , focusing on the intersection of fashion, film, and "editorial elegance" . Her work often features collaborations with makeup artists and photographers to capture what she describes as "quiet luxury". upcoming film projects in the Amsterdam/Antwerp area? Ayesha (@mendesayesha) • Instagram photos and videos

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